diff --git a/lib/compiler/aro/aro/Compilation.zig b/lib/compiler/aro/aro/Compilation.zig
index 0ec314ba83bbbb51d1c98679571dc7b9a6e1b038..222bede46cc2f6a62031a4c0da32fc184081d357 100644
--- a/lib/compiler/aro/aro/Compilation.zig
+++ b/lib/compiler/aro/aro/Compilation.zig
@@ -774,6 +774,11 @@ fn generateSystemDefines(comp: *Compilation, w: *Io.Writer) !void {
                 try w.print("#define __wasm_{s}__ 1\n", .{feature.name});
             }
         },
+        .s390x => {
+            try define(w, "__s390__");
+            try define(w, "__s390x__");
+            try define(w, "__zarch__");
+        },
         else => {},
     }